Facebook PixelCan we target the immune cells to ameliorate the ageing phenotype?
Create newCreate new
Sessions onlySessions only
Ideas onlyIdeas only
Brainstorming session

Can we target the immune cells to ameliorate the ageing phenotype?

Image credit: https://unsplash.com/photos/L7en7Lb-Ovc?utm_source=unsplash&utm_medium=referral&utm_content=creditShareLink

Antonio Carusillo
Antonio Carusillo Dec 03, 2020

[1]Aiello Anna, Farzaneh Farzin, Candore Giuseppina, Caruso Calogero, Davinelli Sergio, Gambino Caterina Maria, Ligotti Mattia Emanuela, Zareian Nahid, Accardi Giulia; Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention Frontiers in Immunology, vol. 10 2019 DOI=10.3389/fimmu.2019.02247

[2]De la Fuente M. (2014) The Immune System, a Marker and Modulator of the Rate of Aging. In: Massoud A., Rezaei N. (eds) Immunology of Aging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-39495-9_2

[3]Glyn Nelson, Olena Kucheryavenko, James Wordsworth, Thomas von Zglinicki, The senescent bystander effect is caused by ROS-activated NF-κB signalling, Mechanisms of Ageing and Development, Volume 170, 2018, Pages 30-36, ISSN 0047-6374, https://doi.org/10.1016/j.mad.2017.08.005.

[4]De la Fuente M. (2018) Oxidation and Inflammation in the Immune and Nervous Systems, a Link Between Aging and Anxiety. In: Fulop T., Franceschi C., Hirokawa K., Pawelec G. (eds) Handbook of Immunosenescence. Springer, Cham. https://doi.org/10.1007/978-3-319-64597-1_115-1

[5]Lingappan K. NF-κB in Oxidative Stress. Curr Opin Toxicol. 2018;7:81-86. doi:10.1016/j.cotox.2017.11.002

[6]De la Fuente M, Miquel J. An update of the oxidation-inflammation theory of aging: the involvement of the immune system in oxi-inflamm-aging. Curr Pharm Des. 2009;15(26):3003-26. doi: 10.2174/138161209789058110. PMID: 19754376.

[7]Moreno-García A, Kun A, Calero O, Medina M, Calero M. An Overview of the Role of Lipofuscin in Age-Related Neurodegeneration. Front Neurosci. 2018;12:464. Published 2018 Jul 5. doi:10.3389/fnins.2018.00464

[8]Carmen Vida, Irene Martínez de Toda, Julia Cruces, Antonio Garrido, Mónica Gonzalez-Sanchez, Mónica De la Fuente, Role of macrophages in age-related oxidative stress and lipofuscin accumulation in mice, Redox Biology, Volume 12, 2017, Pages 423-437, ISSN 2213-2317, https://doi.org/10.1016/j.redox.2017.03.005.

[9]Lloberas J., Tur J., Vico T., Celada A. (2019) Molecular and Cellular Aspects of Macrophage Aging. In: Fulop T., Franceschi C., Hirokawa K., Pawelec G. (eds) Handbook of Immunosenescence. Springer, Cham. https://doi.org/10.1007/978-3-319-99375-1_46

[10]Connie Jackaman, Federica Tomay, Lelinh Duong, Norbaini Bintu Abdol Razak, Fiona J. Pixley, Pat Metharom, Delia J. Nelson, Aging and cancer: The role of macrophages and neutrophils, Ageing Research Reviews, Volume 36, 2017, Pages 105-116, ISSN 1568-1637, https://doi.org/10.1016/j.arr.2017.03.008.

Creative contributions
Know someone who can contribute to this session? Share it with them on , , or

Add your creative contribution

0 / 200

Added via the text editor

Sign up or


Guest sign up

* Indicates a required field

By using this platform you agree to our terms of service and privacy policy.

General comments