Could non-allergic chronic rhinosinusitis be cured by replacing the amalgam dental fillings?
Image credit: Photos taken from https://www.dental-tribune.com/news/bda-northern-ireland-labels-dental-amalgam-phase-out-unworkable/ and https://www.clinicbarcelona.org/en/assistance/diseases/rhinosinusitis/definition and edited.
JuraniumOct 15, 2021
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Is the problem still unsolved?
Is it concisely described?
From time to time, I feel that my nose is really dry and soon after that, I can't feel any smell. Few hours or sometimes even days later, I feel the smell again. I went to see the otorhinolaryngologist and dermatologist multiple times, did tons of tests and checks, to get a lot of unlinked results. The last result of the allergy test showed different allergies than the previous one. Something is weird, but according to them, I have chronic rhinosinusitis.
The new idea I got is inspired by the paper on how severe dermatitis might be caused by a cross‐reaction between nickel and palladium from dental amalgam and was resolved following removal of dental restorations. If the hypersensitivity of the immune system can be caused by metals (as discussed in this contribution), could the high metal concentrations from dental implants account for local chronic inflammation of the upper respiratory tract?
The experiment idea: Linking the non-allergic chronic rhinitis/sinusitis with the hyperreactive immune system due to locally high concentration of metals present in dental fillings
I would first check the prevalence of dental implants in patients with non-allergic chronic rhynitis. Patients would be split in groups according to the number and type of dental implants. Patients without dental implants would be used as a negative control.
The next step would be to measure the concentrations of implant-related (mercury, silver, tin, and copper) and other metals (aluminium, nickel) in the surrounding tissues (upper respiratory tract, neck limph nodes, mouth mucosa, etc).
Finally, the approximately half of the patients would have the dental implants replaced by non-metal ones and subsequently monitored for changes in occurrenceof symptoms of chronic rhynitis.
If the correlation would exist, deeper analysis of immune system activation would be performed.
What do you think about this general design of the experiment?
A similar theory about the negative effects of root canal treatment
Povilas SOct 15, 2021
There is a similar theory of how the fillings used in root canal treatment may cause/influence many chronic diseases. This theory is generally regarded as pseudoscientific by mainstream dentists while often supported by those practicing so-called holistic dentistry. The theory originated from an ~100-year-old medical theory called "focal infection theory". Even though the theory is conspiracy-like, there is some scientific evidence that supports it. There is a quite recent documentary on the matter, which was removed from Netflix likely due to opposition from dental specialists.
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Test patient-specific immune reaction to dental implants in vitro
Michaela DOct 15, 2021
I find the idea of a correlation between chronic inflammation and implants very intriguing!It would be a bit drastic to replace people’s implants without further evidence.Therefore, I would add one step to your experimental design:
*Isolate patients and control immune cells
*Test the reaction of immune cells to different metals, implant-related as well as other metals as a control in vitro. It would be especially interesting to see if the patient’s immune cells show greater reactivity to the specific metal that has been implanted in the patient.
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Positive examples and possible use of lymphocyte reactivity test as a predictive biomarker
JuraniumOct 17, 2021
A study from 2004 showed that 25 (71%) out of 35 patients with autoimmune diseases, which had their dental amalgam replaced, showed a significant decrease in inorganic mercury, silver, organic mercury, and lead levels. The best results were seen in patients with multiple sclerosis. The initial mercury-specific lymphocyte reactivity measured by MELISA® was significantly higher in the responder group than in the non-responders, whose health was not improved by amalgam removal. This could mean that lymphocyte reactivity could be the predictive biomarker of dental amalgam removal in patients with some autoimmune diseases.
A similar effect of amalgam removal was seen in patients with orofacial granulomatosis, who have shown to be allergic to certain metals and positive at the lymphocyte transformation test (the same one used above). After the amalgam removal, 100% of patients showed recovery of the disease symptoms almost within one month.