Can we specifically enrich lipid droplets to fight pathogens and diseases faster and more efficiently?
Image credit: https://biotium.com/product/lipidspot-488-lipid-droplet-stain-1000x/
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Is the problem still unsolved?
Is it concisely described?
- scientists stimulated a bacterial infection in live mice by injecting a bacterial molecule that stimulates the innate immune response
- observed the increase in liver lipid droplets after the activation of the immune system.
- isolated these lipid droplets and compared their antibacterial capacity in vitro
- LPS-induced lipid droplets from the liver were significantly better at killing bacteria
- LPS-induced droplets were enriched with innate immune factors
- the lipid droplets seemed to localize with the bacteria
- incubated human macrophages with fatty acids to increase the number of lipid droplets before the infection
- they inhibited E. coli growth more effectively