Engineered endosymbiosis: what would be some amazing collaborations?
Image credit: National Institutes of Health (NIH)
![Darko Savic](https://cdn.brainstorming.com/47cktp1699882478864.jpg)
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Necessity
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[1]https://en.wikipedia.org/wiki/Symbiogenesis
Creative contributions
Mimic endosymbiosis: models and example
![Antonio Carusillo](https://cdn.brainstorming.com/lhiwda1600618960756.jpg)
[1]Engineering yeast endosymbionts as a step toward the evolution of mitochondria Angad P. Mehta, Lubica Supekova, Jian-Hua Chen, Kersi Pestonjamasp, PaulWebster, Yeonjin Ko, Scott C. Henderson, Gerry McDermott, FrantisekSupek, Peter G. Schultz
[2]Ludington WB, Ja WW (2020) Drosophila as a model for the gut microbiome. PLoS Pathog 16(4): e1008398. https://doi.org/10.1371/journal.ppat.1008398
[3]Nigro G, Hanson M, Fevre C, Lecuit M, Sansonetti PJ. Intestinal Organoids as a Novel Tool to Study Microbes-Epithelium Interactions. Methods Mol Biol. 2019;1576:183-194. doi: 10.1007/7651_2016_12. PMID: 27628134.
[4]Chowdhury, S., Castro, S., Coker, C. et al. Programmable bacteria induce durable tumor regression and systemic antitumor immunity. Nat Med 25, 1057–1063 (2019). https://doi.org/10.1038/s41591-019-0498-z
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Nitrogen fixing bacteria within our skin cells
![Darko Savic](https://cdn.brainstorming.com/47cktp1699882478864.jpg)
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Endosymbiosis engineering for containing anti-oxidant producing bacterial species
[1] Schieber M., Chandel N.S. ROS function in redox signaling and oxidative stress. Curr. Biol. 2014;24:R453–R462. doi: 10.1016/j.cub.2014.03.034
[2]Luo D., Fang B. Structural identification of ginseng polysaccharides and testing of their antioxidant activities. Carbohydr. Polym. 2008;72:376–381. doi: 10.1016/j.carbpol.2007.09.006.
[3]Lin, X., Xia, Y., Wang, G., Yang, Y., Xiong, Z., Lv, F., Zhou, W., & Ai, L. (2018). Lactic Acid Bacteria With Antioxidant Activities Alleviating Oxidized Oil Induced Hepatic Injury in Mice. Frontiers in Microbiology, 9, 1–17. https://doi.org/10.3389/fmicb.2018.02684
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Make the symbiont's DNA incomplete without the host cell's DNA
![Dragan Otasevic](https://cdn.brainstorming.com/blf8en1627056517765.jpeg)
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What causes parts of symbiont's DNA to move to the host cell's nucleus?
![Darko Savic](https://cdn.brainstorming.com/47cktp1699882478864.jpg)
[1]https://microbewiki.kenyon.edu/index.php/Aphids_and_Buchnera
[2]https://en.wikipedia.org/wiki/Blue-ringed_octopus
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Cyanobacteria + nanoparticles + near-infrared light = human photosynthesis
![jnikola](https://cdn.brainstorming.com/m4y0wo1708628053949.png)
[1]https://pubs.acs.org/doi/10.1021/acs.nanolett.1c00719
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Microalgae with antibiotic-loaded polymeric nanoparticles coated with a neutrophil membrane? Done!
![jnikola](https://cdn.brainstorming.com/m4y0wo1708628053949.png)
[1]https://www.nature.com/articles/s41563-022-01360-9
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Magnetosomes from Magnetotactic bacteria
![Darko Savic](https://cdn.brainstorming.com/47cktp1699882478864.jpg)
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Deinococcus radiodurans as safe-keeper of the host cell's DNA
![Darko Savic](https://cdn.brainstorming.com/47cktp1699882478864.jpg)
[1]Minton KW. DNA repair in the extremely radioresistant bacterium Deinococcus radiodurans. Mol Microbiol. 1994 Jul;13(1):9-15. doi: 10.1111/j.1365-2958.1994.tb00397.x. PMID: 7984097.
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General comments
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![Dragan Otasevic](https://cdn.brainstorming.com/blf8en1627056517765.jpeg)
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