Facebook PixelUltrasound guided hair colour therapy
Create newCreate new

Ultrasound guided hair colour therapy

Image credit: Elice Moore/Unsplash

Jamila Nov 09, 2020
Please leave the feedback on this idea

Is it original or innovative?


Is it feasible?


Is it targeting an unsolved problem?


Is it concisely described?

Bounty for the best solution

Provide a bounty for the best solution

Bounties attract serious brainpower to the challenge.

Currency *
Who gets the Bounty *
Can we get rid of grey hair with an ultrasound-guided hair colour therapy?

We all get grey hair at some point in our lives. Researchers suggest that most people get grey hair around the mid-30s, but this varies depending on ethnicity, lifestyle factors, etc. Follicular melanocytes are the cells that produce the pigment called melanin. This pigment is what determines our hair colour. We usually get grey hair because the number of melanocytes decreases.

Stress can induce hair greying. Stress activates the sympathetic nervous system, causing a release of noradrenaline. Noradrenaline depletes the melanocyte stem cells, and so we get grey hair! Noradrenaline can bind to melanocyte stem cells because they have β2 adrenergic receptors on their cell surface.

In a study, Zhang knocked out β2 adrenergic receptors and induced stress in mice, but the mice didn't get grey hair. Furthermore, they used guanethidine on the mice - guanethidine inhibits noradrenaline. Guanethidine prevented the hair from greying when stress was induced in the mice. So, noradrenaline seems to drive the loss of hair colour.

The idea
Try to specifically inhibit the interaction between noradrenaline and the β2 adrenergic receptors on melanocyte stem cells near the hair follicles using ultrasound-guided hair colour therapy!

Ultrasound-guided technology is a delivery method that uses nanoparticles to carry items and an ultrasound to guide the nanoparticles to a specific location in the body. Ryu used the ultrasound-guided method to target the hair follicles before. The researchers were able to reduce SRDA5 levels at the hair follicles using CRISPR - leading to hair growth. Similarly, we could use ultrasounds to target the scalp with the hair colour therapy so that the hair follicles are targeted specifically.

I thought we could either enclose noradrenaline inhibitors, CRISPR, or some other method in the nanoparticles for the hair colour therapy.

Why do we need specific targeting?
Noradrenaline is essential for our bodily processes, such as heart rate, glucose regulation, blood flow, mood, etc. Low levels of noradrenaline can result in depression, ADHD, anxiety, altered heart rate, and much more.

So, altering noradrenaline levels in specific locations might be more beneficial than having high or low levels in the body overall.
  • Which method do you think we should use for hair colour therapy?
  • Are there any limitations to this hair colour therapy?
  • How can I improve the idea?
Let me know what you think.

[1]Kumar, Anagha Bangalore, Huma Shamim, and Umashankar Nagaraju. "Premature graying of hair: review with updates." International journal of trichology 10.5 (2018): 198.

[2]Zhang, Bing, et al. "Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells." Nature 577.7792 (2020): 676-681.

[3]Ryu, Jee-Yeon, et al. "Ultrasound-activated particles as CRISPR/Cas9 delivery system for androgenic alopecia therapy." Biomaterials 232 (2020): 119736.

Creative contributions
Know someone who can contribute to this idea? Share it with them on , , or

Add your creative contribution

0 / 200

Added via the text editor

Sign up or


Guest sign up

* Indicates a required field

By using this platform you agree to our terms of service and privacy policy.

General comments