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What is the rate of re-accumulation of the senescent cells?

Image credit: Chapman et al., 2019 https://febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.13498

Shubhankar Kulkarni
Shubhankar Kulkarni Sep 01, 2020
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What is the rate of re-accumulation of the senescent cells after being eliminated using senolytics or any other mode? Does the type of treatment or dosage affect the rate of re-accumulation?

Senescent cells are eliminated or neutralized with the help of senolytic and senostatic drugs, respectively. The rate of accumulation of senescent cells varies according to age, tissue type, the presence of other age-related diseases, and the inducer of senescence. Is the rate of re-accumulation the same as that of accumulation when the other variables are controlled?

[1]Borghesan M, Hoogaars WMH, Varela-Eirin M, Talma N, Demaria M. A Senescence-Centric View of Aging: Implications for Longevity and Disease. Trends Cell Biol [Internet]. 2020 Aug; Available from: https://linkinghub.elsevier.com/retrieve/pii/S0962892420301434

[2]Kirkland JL, Tchkonia T, Zhu Y, Niedernhofer LJ, Robbins PD. The Clinical Potential of Senolytic Drugs. J Am Geriatr Soc [Internet]. 2017 Oct;65(10):2297–301. Available from: http://doi.wiley.com/10.1111/jgs.14969

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