A metformin and rapamycin drug combination against aging
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- Can a metformin and rapamycin drug combination improve lifespan?
- Can this drug combination improve the hallmarks of aging? like the epigenetic age?
- Would these drugs amplify the geroprotective effects or negate each other?
Cabreiro F, Au C, Leung K-Y, Vergara-Irigaray N, Cochemé HM, Noori T, et al. Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism. Cell [Internet]. 2013 Mar;153(1):228–39. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0092867413002675
Melemedjian, Ohannes K., et al. "Targeting adenosine monophosphate-activated protein kinase (AMPK) in preclinical models reveals a potential mechanism for the treatment of neuropathic pain." Molecular pain 7 (2011): 1744-8069.
Bitto, Alessandro, et al. "Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice." elife 5 (2016): e16351.
Lamming, Dudley W. "Inhibition of the mechanistic target of rapamycin (mTOR)–rapamycin and beyond." Cold Spring Harbor perspectives in medicine 6.5 (2016): a025924.
Castillo-Quan, Jorge Iván, et al. "A triple drug combination targeting components of the nutrient-sensing network maximizes longevity." Proceedings of the National Academy of Sciences 116.42 (2019): 20817-20819.
Some promising findings confirming the validity of this idea
- The most up-to-date (?) study outlining the benefits of rapamycin-metformin synergy in mice.
- An older study showing the effectiveness of rapamycin-metformin synergy in reducing age-dependent oxidative stress in rat erythrocytes.