A metformin and rapamycin drug combination against aging
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Is it original or innovative?
Is it feasible?
Is it targeting an unsolved problem?
Is it concisely described?
- Can a metformin and rapamycin drug combination improve lifespan?
- Can this drug combination improve the hallmarks of aging? like the epigenetic age?
- Would these drugs amplify the geroprotective effects or negate each other?
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Bitto, Alessandro, et al. "Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice." elife 5 (2016): e16351.
Lamming, Dudley W. "Inhibition of the mechanistic target of rapamycin (mTOR)–rapamycin and beyond." Cold Spring Harbor perspectives in medicine 6.5 (2016): a025924.
Castillo-Quan, Jorge Iván, et al. "A triple drug combination targeting components of the nutrient-sensing network maximizes longevity." Proceedings of the National Academy of Sciences 116.42 (2019): 20817-20819.