Facebook PixelDeinococcus radiodurans engineered to take the place of an intracellular organelle in charge of DNA integrity
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Deinococcus radiodurans engineered to take the place of an intracellular organelle in charge of DNA integrity

Image credit: EMSL

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Darko Savic
Darko Savic Oct 14, 2020

[1]https://en.wikipedia.org/wiki/Symbiogenesis

[2]Minton KW. DNA repair in the extremely radioresistant bacterium Deinococcus radiodurans. Mol Microbiol. 1994 Jul;13(1):9-15. doi: 10.1111/j.1365-2958.1994.tb00397.x. PMID: 7984097.

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Darko Savic
Darko Savic3 months ago
D. Radiodurans even survived when exposed to the vacuum of space for 3 years https://youtu.be/O_ZD-uXvlMk
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Martina Pesce
Martina Pesce4 months ago
yes, they talk as these two endonucleases (UvrABC excinuclease and second bona fide endonuclease) are responsible for these repair mechanisms.

I would say that with technologies like CRISPR we could edit the cells' genome so that they also express these molecular machines. Would be cool to see how they react in an in vitro experiment:
-if there are some rejections
-if these two molecular machines fit well in the space and environment
-if they don't unsurprisingly damage other mechanisms that are typically just of humans cells.
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Darko Savic
Darko Savic4 months ago
Here's an interesting experiment of engineered endosymbiosis between e. coli and yeast https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243291/

I wonder what would happen if in a similar fashion, D. radiodurans was made dependent on a host cell and then the host got exposed to high levels of radiation. Would there be any attempt from D. radiodurans to save the host and in so doing save itself?
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Darko Savic
Darko Savic4 months ago
I also wonder how Deinococcus radiodurans deals with the epigenetic drift