Polycomb group of proteins (PcG) suppress the expression of potassium channels in the brain and in cultured neurons. This channel arrest that suppresses the cell membrane permeability to ions is a phenomenon observed in hibernation. This provides neuroprotection in the hypoxia-tolerant, calorie conserving, and hibernating species. 
Both EZH2 ( (Enhancer of Zeste) and CBX7 are members of the Polycomb group of proteins. Interestingly, Polycomb group of proteins also help delay and/or inhibit senescence and can be used as targets for therapy.
A PcG gene Bmi1 (also called PCGF4) is a key requirement for self-renewing cell divisions of both adult hematopoietic stem cells (HSC) and neural stem cells. Several studies demonstrate a role for Bmi1 in preventing senescence. Bmi1–/– fetal liver cells transplanted in mice could differentiate correctly but did not self-renew.  Human fetal lung fibroblasts were shown to have downregulated Bmi1 during senescence but not quiescence.  Bmi1 overexpression in fibroblasts increases life span of mice and man.  Wild-type mouse embryo fibroblasts undergo senescence after 7 to 8 passages in culture, but those from Bmi1–/– undergo only three passages before senescence. It was also shown that re-expression of Bmi1 reversed the premature senescence phenotype and overexpression of Bmi1 increased life span. Also, Sirtuin-2, a longevity protein, is also closely associated with EZH2 and is a part of the Polycomb repressive complex. 
These studies suggest a link across suspended animation, calorie conservation, and longevity.
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