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How to construct an improved synthetic viral vector for molecular therapies?

Image credit: Andre Pelzmann

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Andre Pelzmann
Andre Pelzmann Nov 25, 2020
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Currently one of the most important problems of innovative genome engineering is effective in vivo intracellular delivery of the tissues of interest. All of the common vectors have their limitations. However, now can create an artificial vector that could alloy the best natures of the conventional vectors by the technology of so-called de novo virus synthesis.

The common vectors are:

Adeno-associated Virus AAV:
insert size limit of 4.5kb, requirement of adenovirus or herpes virus for AAV replication, low transduction efficiency, difficult generation of high titers

Poxvirus:
possible cytopathic effects

Herpes Virus:
possible toxicities, risk of recombination

Adenovirus:
transient gene expression, an immune response to viral proteins, insert size limit of 7,5 kb

Retroviral vectors:
transfect only proliferating cells, a concern of insertional mutagenesis, a difficult target of viral infection

Lentiviral vectors:
potential insertional mutagenesis
longevitycrisprmolecular biologygenetic disorders
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