Facebook PixelHow to construct an improved synthetic viral vector for molecular therapies?
Brainstorming
Brainstorming
Create newCreate new
EverythingEverything
Sessions onlySessions only
Ideas onlyIdeas only
Idea

How to construct an improved synthetic viral vector for molecular therapies?

Image credit: Andre Pelzmann

Loading...
Andre Pelzmann
Andre Pelzmann Nov 25, 2020
Please leave the feedback on this idea
Originality

Is it original or innovative?

Feasibility

Is it feasible?

Necessity

Is it targeting an unsolved problem?

Conciseness

Is it concisely described?

Currently one of the most important problems of innovative genome engineering is effective in vivo intracellular delivery of the tissues of interest. All of the common vectors have their limitations. However, now can create an artificial vector that could alloy the best natures of the conventional vectors by the technology of so-called de novo virus synthesis.

The common vectors are:

Adeno-associated Virus AAV:
insert size limit of 4.5kb, requirement of adenovirus or herpes virus for AAV replication, low transduction efficiency, difficult generation of high titers

Poxvirus:
possible cytopathic effects

Herpes Virus:
possible toxicities, risk of recombination

Adenovirus:
transient gene expression, an immune response to viral proteins, insert size limit of 7,5 kb

Retroviral vectors:
transfect only proliferating cells, a concern of insertional mutagenesis, a difficult target of viral infection

Lentiviral vectors:
potential insertional mutagenesis
Creative contributions
Know someone who can contribute to this idea? Share it with them on , , or

Add your creative contribution

0 / 200

Added via the text editor

Sign up or

or

Guest sign up

* Indicates a required field

By using this platform you agree to our terms of service and privacy policy.

General comments