Prescribing a ketone-based diet to prevent or reduce the progression of age-related disease

[1]https://www.un.org/en/sections/issues-depth/population/
[2]https://www.un.org/en/sections/issues-depth/ageing/#:~:text=According%20to%20data%20from%20World,be%20aged%2065%20or%20over.
[3]White, M. C., Holman, D. M., Boehm, J. E., Peipins, L. A., Grossman, M., & Henley, S. J. (2014). Age and cancer risk: a potentially modifiable relationship. American journal of preventive medicine, 46(3 Suppl 1), S7–S15. https://doi.org/10.1016/j.amepre.2013.10.029
[4]McNally MA, Hartman AL. Ketone bodies in epilepsy. J Neurochem. 2012;121(1):28–35.
[5]Cervenka MC, Kossoff EH. Dietary treatment of intractable epilepsy. Continuum (Minneap Minn) [Internet]. 2013;19(June): 756–66. Available from: http://www.ncbi.nlm.nih.gov/pubmed/ 23739109
[6]McDonald, T., & Cervenka, M. C. (2018). Ketogenic Diets for Adult Neurological Disorders. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 15(4), 1018–1031. https://doi.org/10.1007/s13311-018-0666-8
[7]Rieger J, Bähr O, Maurer GD, Hattingen E, Franz K, Brucker D, et al. ERGO: A pilot study of ketogenic diet in recurrent glioblastoma. Int J Oncol. 2014;45(6):1843–52.
[8]Nebeling, L.C., Miraldi, F., Shurin, S.B., Lerner, E., 1995. Effects of a ketogenic diet on tumor metabolism and nutritional status in pediatric oncology patients: two case reports. Journal of the American College of Nutrition 14: 202e208.
[9]Weber, D. D., Aminzadeh-Gohari, S., Tulipan, J., Catalano, L., Feichtinger, R. G., & Kofler, B. (2020). Ketogenic diet in the treatment of cancer - Where do we stand?. Molecular metabolism, 33, 102–121. https://doi.org/10.1016/j.molmet.2019.06.026
[10]Kudryavtseva, A. V., Krasnov, G. S., Dmitriev, A. A., Alekseev, B. Y., Kardymon, O. L., Sadritdinova, A. F., Fedorova, M. S., Pokrovsky, A. V., Melnikova, N. V., Kaprin, A. D., Moskalev, A. A., & Snezhkina, A. V. (2016). Mitochondrial dysfunction and oxidative stress in aging and cancer. Oncotarget, 7(29), 44879–44905. https://doi.org/10.18632/oncotarget.9821
[11]Maalouf M, Rho JM, Mattson MP. The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies. Brain Res Rev [Internet]. Elsevier B.V.; 2009;59(2):293–315. https:// doi.org/10.1016/j.brainresrev.2008.09.002
[12]Taylor MK, Sullivan DK, Mahnken JD, Burns JM, Swerdlow RH. Feasibility and efficacy data from a ketogenic diet intervention in Alzheimer’s disease. Alzheimer’s Dement Transl Res Clin Interv. Elsevier Inc.; 2018;4:28–36.
[13]Reger MA, Henderson ST, Hale C, Cholerton B, Baker LD, Watson GS, et al. Effects of β-hydroxybutyrate on cognition in memory-impaired adults. Neurobiol Aging. 2004;25(3):311–4.
[14]Ota M, Matsuo J, Ishida I, Hattori K, Teraishi T, Tonouchi H, et al. Effect of a ketogenic meal on cognitive function in elderly adults: potential for cognitive enhancement. Psychopharmacology (Berl)
[15]Henderson ST, Vogel JL, Barr LJ, Garvin F, Jones JJ, Costantini LC. Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer’s disease: a randomized, double-blind, placebo-controlled, multicenter trial. Nutr Metab (Lond) [Internet]. 2009;6(1):31. Available from: http://nutritionandmetabolism. biomedcentral.com/articles/10.1186/1743-7075-6-31
[16]Rebello CJ, Keller JN, Liu AG, Johnson WD, Greenway FL. Pilot feasibility and safety study examining the effect of medium chain triglyceride supplementation in subjects with mild cognitive impairment: A randomized controlled trial. BBA Clin. The Authors; 2015;3:123–5.
[17]Yin Y, Wang Z. ApoE and Neurodegenerative Diseases in Aging. Adv Exp Med Biol. 2018;1086:77-92. doi: 10.1007/978-981-13-1117-8_5. PMID: 30232753.
[18]Franceschi C & Campisi J (2014) Chronic inflammation(inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci 69(Suppl 1), S4–S9.
[19]Sanada F, Taniyama Y, Muratsu J, Otsu R, Shimizu H,Rakugi H & Morishita R (2018) Source of chronicinflammation in aging. Front Cardiovasc Med 5, 12.
[20]Franceschi C, Garagnani P, Vitale G, Capri M &Salvioli S (2017) Inflammaging and ‘Garb-aging’.Trends Endocrinol Metab 28, 199–212
[21]Koppel SJ, Swerdlow RH. Neurochemistry International Neuroketotherapeutics: A modern review of a century-old therapy. Neurochem Int [Internet]. Elsevier Ltd; 2017; https://doi.org/ 10.1016/j.neuint.2017.05.019
[22]Cullingford TE. The ketogenic diet; fatty acids, fatty acidactivated receptors and neurological disorders. Prostaglandins Leukot Essent Fat Acids. 2004;70(3):253–64.
[23]Youm Y, Nguyen KY, Grant RW, Goldberg EL, Bodogai M, Kim D, et al. The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nat Med [Internet]. Nature Publishing Group; 2015;21(3):263–9. https:// doi.org/10.1038/nm.3804
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