Using CRISPR for a novel senolytic therapy
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- BCL-2 family (BCL-2, BCL-XL, etc.)
- Which gene(s) should be targeted?
- How will the senescent cells be specifically targeted?
- Are CRISPR based transcriptional regulators the best option to go with?
- Can genes be upregulated and downregulated simultaneously with CRISPR?
- How long would the CRISPR components stay in the body?
- Suppose things went wrong like for example healthy cells being targeted. How could we ensure safety?
Yosef, Reut, et al. "Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL." Nature communications 7.1 (2016): 1-11.
Adli, Mazhar. "The CRISPR tool kit for genome editing and beyond." Nature communications 9.1 (2018): 1-13.
Maeder, Morgan L., et al. "CRISPR RNA–guided activation of endogenous human genes." Nature methods 10.10 (2013): 977-979.
Kirkland, James L., and Tamara Tchkonia. "Cellular senescence: a translational perspective." EBioMedicine 21 (2017): 21-28.