Idea
Could Breathomics Be Used as a Marker of Aging?
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By Jamila Ahmed on Aug 14, 2020
[1] Montuschi, Paolo, et al. "Increased 8-isoprostane, a marker of oxidative stress, in exhaled condensate of asthma patients." American journal of respiratory and critical care medicine 160.1 (1999): 216-220.
[2] Greulich, Timm, et al. "Obstructive sleep apnea patients can be identified by ion mobility spectrometry-derived smell prints of different biological materials." Journal of breath research 12.2 (2018): 026006.
[3] Sethi, Shneh, Ranjan Nanda, and Trinad Chakraborty. "Clinical application of volatile organic compound analysis for detecting infectious diseases." Clinical microbiology reviews 26.3 (2013): 462-475.
[4] O’Hara, M. E., et al. "Limonene in exhaled breath is elevated in hepatic encephalopathy." Journal of breath research 10.4 (2016): 046010.
This is a great idea! Although studies focusing on healthy older subjects (greater than 50 years of age) have not yet identified any significant compounds or “breathprints”, [1] age-related diseases seem to have marker VOCs [2] . For now, probably the best way to go would be to list the VOCs for each of the age-related diseases and score them based on their frequency. We can use a threshold to identify the prominent ones and then check their levels / presence in older people and compare those with those in young adults. References: 1. https://www.scielo.br/scielo.php?pid=S1806-37132016000200143&script=sci_arttext 2. https://www.sciencedirect.com/science/article/pii/B978012816413600023X#:~:text=Acetone%2C%20ethanol%2C%20isoprene%2C%20isopropanol,healing%20progress%20in%20diabetes%20patients. ...
Multiple sclerosis could be detected via a breath test as well https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369719/...
That's great! ...
Amazing idea! Sounds like a perfect job for AI and a ton of data to analzyze. I know just the guy to consult on viability of such an idea...